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Gabpentin is an FDA-licensed medication used in the treatment of epileptic seizures, neuropathy pain, and moderate and severe restless legs syndrome. Using Gabapentin for sleep falls under off-label use.

But how does Gabapentin help you sleep? To answer this question we must understand how gabapentin works. Gabapentin is an analog of GABA (Gamma-aminobutyric acid) that works as the primary inhibitory neurotransmitter. When you take gabapentin, it produces the effects of GABA and makes you feel relaxed all of a sudden. This happens because Gabapentin calms down the overactive nerve cells which are firing rapidly and your brain fails to process that. This calming sensation makes you feel sleepy.

Patients who were treated with gabapentin showed remarkable results. Studies have displayed that taking Gabapentin has potentially improved slow-wave deep sleep. It is also revealed that Gabpentin has made sleep quality better.